Effect of Pretrapping of Microbubbles in Sonoporation Using N-Isopropylacrylamide Gel Flow Channel Phantom
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概要
- 論文の詳細を見る
It is considered that sonoporation, which produces small pores through a cell membrane, is a sophisticated tool for improving the efficacy of ultrasonic-wave-irradiated drug delivery systems. However, neither the precise mechanism of pore production nor the optimum conditions of insonation have been clarified yet. In this study, the microscopic observation of micron size hollows produced on the wall of an optical transparent gel by bubble cavitation is performed in order to evaluate sonoporation. As a gel phantom, we adopted N-isopropylacrylamide (NIPA) gel, which has almost the same acoustic properties as soft tissue and is optically transparent below the metastasis temperature. Using the gel phantom, the effect of the pretrapping of microbubbles, which is carried out immediately before irradiating a high-intensity ultrasonic wave to prepare the bubble conditions required for sonoporation, is evaluated.
- Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
- 2010-07-25
著者
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Yamakoshi Yoshiki
Faculty Of Engineering Department Of Electric And Electronic Engineering Gunma University
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Miwa Takashi
Faculty Of Electro-communications The University Of Electro-communications
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Miwa Takashi
Faculty of Engineering, Gunma University, 1-5-1 Tenjincho, Kiryu, Gunma 376-8515, Japan
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Yoshizawa Nobuyuki
Faculty of Engineering, Gunma University, 1-5-1 Tenjincho, Kiryu, Gunma 376-8515, Japan
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Inoguchi Hiroki
Faculty of Engineering, Gunma University, 1-5-1 Tenjincho, Kiryu, Gunma 376-8515, Japan
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Zhang Dongyu
Faculty of Engineering, Gunma University, 1-5-1 Tenjincho, Kiryu, Gunma 376-8515, Japan
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