Noise Reduction of Carbon Nanotube Field-Effect Transistor Biosensors by Alternating Current Measurement

概要

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We demonstrated a marked improvement of sensitivity (signal-to-noise ratio) in carbon nanotube field-effect transistor (CNTFET) sensors. The alternating current (AC) measurement with a lock-in amplifier, which suppresses the fluctuations in drain current in CNTFETs without decreasing the signal level, was adopted. The noise level of CNTFETs used in buffer solutions was greatly decreased by AC measurement. Furthermore, we investigated the sensing operations of CNTFET pH sensors and biosensors by AC measurement. The sensing performance of CNTFET sensors was markedly improved. The signal-to-noise ratio of pH sensors measured using AC was six times higher than that obtained by direct current (DC) measurement. A small amount of bovine serum albumin of 250 pM was effectively detected by CNTFET biosensors by AC measurement.
Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
2009-06-25