Development of Atomic Force Microscope for Arthroscopic Knee Cartilage Inspection
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概要
- 論文の詳細を見る
A recent study, based on ex vivo unconfined compression testing of normal, diseased, and enzymatically altered cartilage, revealed that a scanning force microscope (SFM), used as a nano-intender, is sensitive enough to enable measurement of alterations in the biomechanical properties of cartilage. Based on these ex vivo measurements, we have designed a quantitative diagnosis tool, the scanning force arthroscope (SFA), able to perform in vivo measurements during a standard arthroscopic procedure. For stabilizing and positioning the instrument relative to the surface under investigation, a pneumatic system has been developed. A segmented piezoelectric tube was used to perform the indentation displacement, and a pyramidal nanometer-scale silicon tip mounted on a cantilever with an integrated deflection sensor measured the biomechanical properties of cartilage. Mechanical means were designed to protect the fragile cantilever during the insertion of the instrument into the knee joint. The stability of the pneumatic stage was checked with a prototype SFA. In a series of tests, load-displacement curves were recorded in a knee phantom and, more recently, in a pig's leg.
- Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
- 2006-03-15
著者
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De Rooij
Institute Of Microtechnology University Of Neuchatel
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Staufer Urs
Institute Of Microtechnology University Of Neuchatel
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Akiyama Terunobu
Institute Of Microtechnology University Of Neuchatel
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Staufer Urs
Institute of Microtechnology, University of Neuchatel, Jaquet-Droz 1, CH-2002 Neuchatel, Switzerland
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Imer Raphael
Institute of Microtechnology, University of Neuchatel, Jaquet-Droz 1, CH-2002 Neuchatel, Switzerland
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Stolz Martin
Maurice E. Mueller Institute, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland
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Aebi Ueli
Maurice E. Mueller Institute, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland
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Friederich Niklaus
Clinics for Orthopaedic Surgery and Traumatology, Kantonsspital Bruderholz, CH-4101 Bruderholz, Switzerland
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Koenig Uwe
Clinics for Orthopaedic Surgery and Traumatology, Kantonsspital Bruderholz, CH-4101 Bruderholz, Switzerland
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Wirz Dieter
Laboratory for Orthopaedic Biomechanics, University of Basel, Klingelbergstrasse 50-70, CH-4056 Basel, Switzerland
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Daniels A.
Laboratory for Orthopaedic Biomechanics, University of Basel, Klingelbergstrasse 50-70, CH-4056 Basel, Switzerland
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Akiyama Terunobu
Institute of Microtechnology, University of Neuchatel, Jaquet-Droz 1, CH-2002 Neuchatel, Switzerland
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