Self-Assembled Nanoparticles of Ribozymes with Poly(ethylene glycol)-$b$-Poly(l-lysine) Block Copolymers
スポンサーリンク
概要
- 論文の詳細を見る
Complex nanoparticle formation of poly(ethylene glycol)-$b$-poly(l-lysine) (PEG-$b$-PLL) block copolymers with ribozyme (Rzs) in an aqueous solution was studied. Nanoparticles formed from PEG-$b$-PLL and Rzs have about 100 nm in an effective diameter with the hydrophilic PEG segments stabilizing and surrounding the core of complexes formed between the PLL segments and Rzs. The block copolymer having a higher positive charge formed relatively smaller complex nanoparticles. The profile of the ethidum bromide (EtBr) displacement assay and images of agarose gel electrophoresis revealed the condensation of Rzs to form complex nanoparticles above a critical weight ratio, $r$ ($r$: 4.0 for PEG5000-$b$-PLL1920 and 3.0 for PEG5000-$b$-PLL3840). Furthermore, the PEG-$b$-PLL/Rz complex nanoparticle showed high resistance against RNase attack in biological fluids.
- Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
- 2006-01-15
著者
-
KIM Jong-Duk
Department of Chem. Eng., Korean Advanced Institute of Science and Technology
-
Park Kinam
Departments Of Pharmaceutics And Biomedical Engineering Purdue University
-
Jeong Jae
Department of Electrical & Semiconductor Engineering, Yosu National University, San 96-1 Dundeck-dong, Yeosu-si, Jeollanam-do, 550-749 Korea
-
Cho Yong
Asan Institute for Life Sciences, University of Ulsan College of Medicine, 388-1 Pungnap-2 dong, Songpa-gu, Seoul 138-736, Republic of Korea
-
Kim Jong-Duk
Department of Chemical and Biomolecular Engineering, and Center for Ultramicrochemical Process Systems, Korea Advanced Institute of Science and Technology, Kusong-dong, Yusong-gu, Daejon 305-701, Republic of Korea
-
Jung Bokyung
Department of Chemical and Biomolecular Engineering, and Center for Ultramicrochemical Process Systems, Korea Advanced Institute of Science and Technology, Kusong-dong, Yusong-gu, Daejon 305-701, Republic of Korea
-
Jeong Jae
Department of Chemical and Biomolecular Engineering, and Center for Ultramicrochemical Process Systems, Korea Advanced Institute of Science and Technology, Kusong-dong, Yusong-gu, Daejon 305-701, Republic of Korea
関連論文
- The clinical impact of ^F-FDG PET in papillary thyroid carcinoma with a negative ^I whole body scan : a single-center study of 108 patients
- Correlation between serum CEA level and metabolic volume as determined by FDG PET in postoperative patients with recurrent colorectal cancer
- NON-ISOTHERMAL ADSORPTION OF NITROGEN-CARBON DIOXIDE MIXTURE IN A FIXED BED OF ZEOLITE-X
- Photorefractivity and Optical Transmittance of Hybrid Liquid Crystal Cell With Homeotropically Photoaligned Layer and Fullerene Initiation : Optical Properties of Condensed Matter
- Second Harmonic Generation and Photorefractive Effect in Dye-Doped Liquid Crystals : Optics and Quantum Electronics
- Comparison of FDG-PET findings of brain metastasis from non-small-cell lung cancer and small-cell lung cancer
- The effect of tumor size on F-18-labeled fluorodeoxyglucose and fluoroerythronitroimidazole uptake in a murine sarcoma model
- Efficacy of endoscopic subureteral injection for vesicoureteral reflux in adults with decreased bladder compliance
- Palmitoyl Lysozyme-induced Stabilizatio of PE (Phosphatidylethanolamine0 Liposomes nad Their Interaction with Candida albicans
- Meyer–Neldel Rule and Extraction of Density of States in Amorphous Indium–Gallium–Zinc-Oxide Thin-Film Transistor by Considering Surface Band Bending
- A Glucose Sensor Fabricated by Piezoelectric Inkjet Printing of Conducting Polymers and Bienzymes
- Temperature-Sensitivity of Loposomal Lipid Bilayers Mixed with Poly(N-Isopropylacrylamide-co-acrylic Acid)
- Analysis of consumers' preferences and behavior with regard to horse meat using a structured survey questionnaire
- Etch Defect Reduction Using SF6/O2 Plasma Cleaning and Optimizing Etching Recipe in Photo Resist Masked Gate Poly Silicon Etch Process
- JKCF1-6 Endoplasmic reticulum stress is implicated in the pathogenesis of severe asthma(Inflammatory cells in allergic diseases,Free Paper Session 1,Japan-Korea-China Joint Symposium)
- GENERALIZED STRONGLY NONLINEAR QUASI-VARIATIONAL INEQUALITIES(NONLINEAR ANALYSIS AND CONVEX ANALYSIS)
- Grating Formation Time of Photorefractive Liquid Crystal Cell with Mixed Layer of PVK and $p$-PMEH-PPV
- Binding Evaluation of Targeted Microbubbles with Biotin–Avidin Interaction by Surface Plasmon Resonance Biosensor
- Self-Assembled Nanoparticles of Ribozymes with Poly(ethylene glycol)-$b$-Poly(l-lysine) Block Copolymers
- Kinetics of Reduction of Uranium (VI) to Uranium (IV) at Titanium Electrode in Nitric Acid and Hydrazine Media.
- Temperature-Sensitivity of Liposomal Lipid Bilayers Mixed with Poly(N-Isopropylacrylamide-co-acrylic Acid).
- Palmitoy Lysozyme-Induced Stabilization of PE (Phosphatidylethanolamine) Liposomes and Their Interaction with Candida albicans.