Room Temperature Operation of a Coulomb Blockade Sensor Fabricated by Self-Assembled Gold Nanoparticles using Deoxyribonucleic Acid Hybridization
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概要
- 論文の詳細を見る
Molecules of 3-mercaptopropyltrimethoxysilane react with gold nanoparticles to form a gold monolayer on a silicon dioxide substrate. The 12-mer capture Deoxyribonucleic acid (DNA) self-assembles with the nanometer-sized gold particles. Prior to DNA hybridization, a capture DNA produced via hybridization of the target and probe oligonucleotides is covalently bonded to the gold particles. In addition, the probe oligonucleotide containing a thiol group can self-assemble with additional gold nanoparticles, and multilayered structures are thereby fabricated. The device, assembled only with gold nanoparticles and without DNA immobilization, has no quantum effect conductivity, while a DNA sensor assembled from 4 nm gold nanoparticles and oligonucleotides exhibits Coulomb blockade. The measurement of the tunneling current as a function of applied voltage for the Coulomb blockade DNA sensor is reproducible. Using 14 nm gold nanoparticles instead, the Coulomb blockade for the DNA sensor only occurs at temperatures below 150 K.
- Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
- 2004-06-15
著者
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KO Fu-Hsiang
National Nano Device Lab.
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CHEN Chun-Chi
National Nano Device Laboratories
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Chen Hsuen-li
National Nano Device Lab.
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Pun Chung-ching
Department Of Mechanical Engineering National Taiwan University
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Tsai Chien-ying
Department Of Mechanical Engineering National Taiwan University
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Chen Ping-hei
Department Of Mechanical Engineering National Taiwan University
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Pun Chung-Ching
Department of Mechanical Engineering, National Taiwan University, Taipei 106, Taiwan
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Ko Fu-Hsiang
National Nano Device Laboratories, 1001-1, Ta-Hsueh Rd., Hsinchu 300, Taiwan
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Chen Ping-Hei
Department of Mechanical Engineering, National Taiwan University, Taipei 106, Taiwan
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Chen Hsuen-Li
National Nano Device Laboratories, 1001-1, Ta-Hsueh Rd., Hsinchu 300, Taiwan
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Tsai Chien-Ying
Department of Mechanical Engineering, National Taiwan University, Taipei 106, Taiwan
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Chen Chun-Chi
National Nano Device Laboratories, 1001-1, Ta-Hsueh Rd., Hsinchu 300, Taiwan
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