ラット末梢交感神経束内microstimulationが血糖値に及ぼす効果
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概要
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We recently reported that stimulation of a peripheral sympathetic nerve fascicle via a microelectrode, i.e. microstimulation, transiently reduced blood glucose (BG) in rats in case that its intensity was set to induce small muscle contraction (MC). The reduction could be attributed to the enhancement of peripheral glucose uptake (GU). We then found that the peripheral sympathetic nerve activity can be enhanced with microstimulation intensity lower than the MC threshold (MCT). In the present study, therefore, effects of the microstimulation on BG and plasma insulin (PI) were evaluated with intensity lower than or equal to (MCT-0.05) V. The results showed that BG successfully decreased in 30 s and returned toward the baseline thereafter, as seen in the previous study shown above, with little change in PI. They suggest that the microstimulation could increase peripheral GU to reduce BG without MC, and that the function could be non-insulin dependent.
- 一般社団法人 日本生体医工学会の論文
一般社団法人 日本生体医工学会 | 論文
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