Characteristic changes in systemic blood pressure in eclampsia

概要

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Aim: It has been reported that eclampsia might be caused by vasogenic edema from impaired autoregulation of cerebral blood flow, potentially due to elevated systemic blood pressure (BP). This study retrospectively investigated changes in systemic BP around eclampsia onset.Methods: Eight women with eclampsia were enrolled. Three received antihypertensive drugs. Four had labor pains. Systolic and diastolic BP and heart rate were evaluated. Mean arterial pressure (MAP) and changes in BP (ΔBP) just before and after eclampsia onset were calculated.Results: Systemic BP markedly increased just before eclampsia onset, then decreased to lower than before onset. The ΔBP1 (each BP just before eclampsia onset−mean BP) was 21±9 mmHg (21±11%), and the ΔBP2 (each BP just after eclampsia onset−BP just before eclampsia onset) was −40±18 mmHg (−31±12%) in MAP. The heart rate rapidly increased just after onset (75±8 vs. 128±6 bpm). Fetal cardiac monitoring showed prolonged deceleration in all pregnant patients.Conclusions: It was suggested that both marked increase and decrease in BP around the onset of eclampsia might cause strong damage in not only maternal but also fetal blood circulation.
日本妊娠高血圧学会の論文