Suppressive Effects of Standard-dose Rosuvastatin Therapy on the Progression of Coronary Atherosclerosis in Japanese Patients: The APOLLO Study

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概要

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• Aim: We used quantitative coronary angiography (QCA) to investigate whether coronary plaque progression can be inhibited by controlling lipids with rosuvastatin at Japanese standard doses following elective percutaneous coronary intervention (PCI).Methods: A total of 143 patients who underwent elective PCI were randomized to either the rosuvastatin (5 or 2.5mg/day) or non-statin group. Changes from baseline in the minimal lumen diameter (MLD) and average lumen diameter (ALD) measured using QCA were analyzed in both target and non-target lesions.Results: The changes in MLD and ALD from baseline to 24 months in the non-target lesions were significantly smaller in the rosuvastatin group than in the non-statin group (−0.079±0.014 mm vs.−0.135±0.019 mm, p=0.022; −0.062±0.012 mmvs. −0.109±0.016mm, p=0.025). The changes in MLD from six to 24 months in the target lesions were significantly lower in the rosuvastatin group than in the non-statin group among the patients treated with drug-eluting stents (−0.046± 0.108 mm vs. −0.133±0.108 mm, p=0.009) versus those treated with bare-metal stents (−0.011± 0.094 mm vs. −0.015±0.040 mm, p=0.255).Conclusions: The present study demonstrated that the administration of a standard dose of rosuvastatin slows coronary plaque progression and may prevent the late catch-up phenomenon associated with drug-eluting stents in patients who undergo elective PCI.

• 一般社団法人 日本動脈硬化学会の論文

著者

• Goya Masahiko

  Department Of Cardiology Kokura Memorial Hospital

• Iwabuchi Masashi

  Department Of Blood Purification Tohoku University Graduate School Of Medicine

• Shirai Shinichi

  Department Of Cardiology Kokura Memorial Hospital

• Ando Kenji

  Department Of Applied Chemistry Nagoya Institute Of Technology

• Amemiya Kisaki

  Department Of Cardiology Kokura Memorial Hospital

• Yokoi Hiroyoshi

  Department Of Cardiac Rehabilitation Kokura Memorial Hospital

• DOMEI Takenori

  Department of Cardiology, Kokura Memorial Hospital

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