実験的腰痛における機能的MRIを用いた疼痛関連脳活動の検討
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Introduction: Low back pain (LBP) is often reported as dull pain in the deep, musculoskeletal system around the lumbar spine. Although the chronic LBP could potentially involve the supraspinal pathology, its cerebral substrates have not been defined. We have developed a human model of LBP to identify such substrates by functional magnetic resonance imaging (fMRI) and further to investigate the plastic changes that may underlie the chronic progression of LBP. Methods: Six healthy volunteers, laid in the prone position in a 3-Tesla MRI scanner, were stimulated with a tail of an occluded disposable 20-ml syringe, filled with 25-ml air, orthogonally placed at 5 cm lateral to the L4/5. Calibrated, manual pressure was applied on the syringe so that each subject reported pain intensity at either 3 or 5 out of 10-cm visual analogue scale (VAS). Three blocks of 30-s pain stimulus, at either 3 or 5 of VAS, were given with 30-s intervening rest conditions, while the whole-brain gradient-echo echo-planar imaging, optimized for blood oxygenation level-dependent (BOLD) contrast, was performed. Functional data were aligned with each subjects 3-dimentional high-resolution image obtained during the same session, and analyzed with general linear model using BrainVoyager QX (BrainInnovation, Maastricht, Netherlands). After being averaged across subjects, the cerebral activation map was obtained with the false discovery rate at q<0.05. Results: The average force required to induce pain at the VAS of 3 and 5 was 376 ± 72 kPa and 538 ± 66 kPa, respectively. Pain at the VAS of 3 and 5 commonly activated the prefrontal cortex and the supplementary motor area at nearly the same BOLD amplitude, but spared the primary and secondary somatosensory cortices. Discussion: The present model of LBP induced cerebral activation in the medial nociceptive system and the motor-related areas, but did not show any activation in the lateral nociceptive system. Such lack of somatotopic representation might indicate that the present model of LBP involves the deep, heterogeneous structures around the lumbar spine.
- 日本疼痛学会の論文
日本疼痛学会 | 論文
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