顎関節C-ポリモーダル侵害受容器に対する抗炎症薬の効果:──ラットin vitro標本による解析──
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概要
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We have reported that polymodal nociceptors are abundant in the temporomandibular joint (TMJ) region and that a lowered threshold of polymodal nociceptors is involved in TMJ pain (Takeuchi et al., 2001, 2003). In this study, we compared the effects of steroidal and non-steroidal anti-inflammatory drugs (SAID and NSAID, respectively) on the responses of C-Polymodal units, using an in vitro TMJ-nerve preparation. Male Wistar albino rats weighing about 250 - 350 g were used. Recordings were obtained from C-Polymodal units identified by its conduction velocity (below 2.0 m/s) and responsiveness to mechanical, thermal and chemical stimuli. Nociceptive responses were induced by topical administration of bradykinin (BK) to the TMJ area, while single unit activities were recorded from auricular-temporal nerve filaments by a tungsten microelectrode. In addition, nociceptive threshold was measured by von Frey hair stimulation during drug application. The frequency of the BK-induced unit activity and the mechanical nociceptive threshold were recorded before and after application of SAID (dexamethasone), NSAID (flurbiprofen), or physiological saline (control group). Dexamethasone and flurbiprofen significantly decreased the BK-induced nociceptive responses. The nociceptive threshold increased after application of anti-inflammatory drugs, indicating that bradykinin-induced mechanical sensitization was well inhibited by SAID and NSAID. Effect of dexamethasone was expressed immediately after its application, while that of flurbiprofen was expressed after a period of latency. These results show that different antiinflammatory drugs have different anti-nociceptive properties and that the adequate analgesic drug should be applied in the clinical field according to the type of TMJ pain.
- 日本疼痛学会の論文
日本疼痛学会 | 論文
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