Vocalization Induced by Electrical Brainstem Stimulation in Ketamine Anesthetized Cats:An Experimental Model for Vocalization

概要

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Vocalization was induced by repetitive electrical stimulation (0.2 ms, 60-200Hz, 30-300μA, 5-10 s) of the midbrain and pons using a tungsten microelectrode under light Ketamine anesthesia (40mg/Kg i.m.) in cats. Effective sites were localized in the ventrolateral part of the periaqueductal gray (PAG), the midbrain reticular formation (RF) near PAG from the level of the rostral superior colliculus (SC) to the middle SC, and in the ventrolateral pontine RF near the pyramidal tract, and the medial lemniscus from the level of the middle SC to the inferior colliculus (IC). Furthermore, from the level of the middle SC to the caudal SC, the effective sites were localized in the lateral part of the pontine RF. The acoustic characteristics of the induced vocalization were analyzed by means of FFT with 20 Hz resolution every 50 ms for 3 s. Acoustic analysis by FFT revealed that there were no significant differences in the fundamental frequency and formant components between the spontaneous and induced vocalization. When stimulus frequency was changed, the harmonic structure of the power spectrum varied slightly, although there were no significant differences in the fundamental frequency. When the stimulation site was changed from the rostral to the caudal position, no significant difference was found in fundamental frequency of the induced vocalization.
The Japan Laryngological Associationの論文