Photodynamic Therapy for early laryngeal cancer
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概要
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Radiotherapy for early laryngeal cancer has already been in widespread clinical use as an established therapy. However, radiation induced cancer is possibly to be problematic as that the average life span of the patient is now prolonged. The authors have tried to apply photodynamic therapy (PDT); administration of hematoporphyrin derivative (HpD) and irradiation with low energic laser, for early laryngeal cancer and recurrent ones.<BR>As a prliminary report, this paper describes 6 patients with vocal cord cancer undergone PDT from February 1988 to January 1989. These patients consisted of 1 case of T<SUB>1</SUB>, 3 cases of Tis and 2 recurrent cases after irradiation therapy.<BR>HpD was injected intravenously at 48-72 hours before laser irradiation, and laser was applied under general anesthesia. The basic laser dose were 200-500mW/cm<SUP>2</SUP> with continuous wave for 20 min for Argon-dye laser and 3-4 mJ/P (30 Hz) with pulse wave for Eximer-dye laser.<BR>In all of 4 cases of initial treatment, the tumor has been controlled for 18 months or more. In 1 recurrent case after radiation therapy, no further relapse has occurred for 28 months after PDT. Total laryngectomy was performed on the remaining 1 patient because of the recurrence after PDT. Histological examination of the resected larynx revealed that there was necrotic tissue up to the depth of 2mm and existence of cancer cells in the deeper layer and glands.<BR>The author's impression is that more poweful laser, more effective chemical substance with exciting wave length of 600 nm and all direction illuminator should be needed for more popular use of PDT in laryngeal cancer, although PDT is a promising treatment for vocal cord cancer.
- The Japan Laryngological Associationの論文
The Japan Laryngological Association | 論文
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