Regenerative Medicine of the Airway Tract

概要

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Airway reconstruction after resection of malignancies or stenotic inflammatory lesions after traumatic injury is one of the most difficult procedures. To provide functional regeneration of the airway, we used<I> in situ</I> Tissue Engineering technique. As the tissue scaffold, Marlex mesh reinforced with polypropylene rings covered by a collagen sponge was developed. This scaffold material was implanted in animal models. After the safety and the utility were confirmed in the animal studies, the current regenerative technique was applied in human clinical cases with good results. However the growth speed of the tracheal epithelium over the artificial material was slow. To solve this problem, we tried to develop a hybrid material with which to cover the epithelium of the trachea. In this paper we report the basic research results of tissue engineering for the airway tract to date and of its clinical application. Furthermore, we report our current development of the hybrid artificial material.
The Japan Laryngological Associationの論文