Expression of Basic Fibroblast Growth Factor in the Nucleus Ambiguus in Rats following Unilateral Recurrent Laryngeal Nerve Injury
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概要
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Basic fibroblast growth factor (bFGF), which is a member of fibroblast growth factor family, has been demonstrated to play important roles in neural development and regeneration. In this study, we investigated the expression pattern of bFGF in the rat nucleus ambiguus (NA) following unilateral recurrent laryngeal nerve (RLN) injury and discussed the roles of bFGF on neural regeneration.<BR>This study involved thirty-three rat subjects. In the first group (n=15), the left RLN was crushed with forceps at the location of the seventh tracheal ring. In the second group (n=15), the left RLN was resected for 5mm in length. The brainstems of rats were excised on the 1st, 3rd, 7th, 14th and 28th days after the procedure in both groups. In the normal group (n=3), rats served as controls. The brainstems were rapidly frozen and 20μ m-thick serial sections were cut on a cryostat. The sections were processed for immunohistochemical staining using anti-bFGF antibody. The expression of bFGF in the NA was quantitatively evaluated via an image analysis technique.<BR>Although a weak expression of bFGF in the NA was identified in the normal group, the expression had increased in the crushed and resected groups. In particular, bFGF was expressed up to 7 times as much as in the untreated side on the 14th day following RLN resection.<BR>These findings suggest that the expression of bFGF in the NA is promoted by RLN injury and that it is deeply associated with a regeneration of the injured nerve by preventing lesion-induced neural death.
- The Japan Laryngological Associationの論文
The Japan Laryngological Association | 論文
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