腱板断裂断端における腱細胞増殖能

概要

論文の詳細を見る
To understand the mechanism of tendon cell proliferation eventually leads to stimulate the natural healing potential of the ruptured rotator cuff tendon. The aim of this study was to examine the proliferative activity of the tendon cells in torn supraspinatus tendon. Samples were collected from patients with full thickness rotator cuff tears undergoing shoulder surgeries. Tendon cell proliferation was assessed by immunolocalization of PCNA. The proliferative index measured by a computer system. We could detect proliferating tendon cells in our rotator cuff tendon samples by immunohistochemical analysis of the PCNA. The tendon cells in the distal area were significantly more proliferating compared to the proximal area. The proliferative index in the distal area for the large and massive size tear group was significantly higher compared to the small and middle size tear group. The proliferative index in the proximal area were the same. The proliferative activity of the tendon cell remained after the rotator cuff tear. It was strongly related to the location of the torn tendon and the tear size. This contributed to our understanding of the enhancement of the healing potential of untreated and surgically treated rotator cuff tendons.
Japan Shoulder Societyの論文