Photodynamic Therapy (PDT) for the Atherosclerosis
スポンサーリンク
概要
- 論文の詳細を見る
Recently, the effects of photodynamic therapy (PDT) on atherosclerosis using Hematoporphyrine derivative (HpD), a photosensitive material, have been reported. This study was performed to evaluate the possibility of inducing regression of atherosclerotic foci by photodynamic therapyusing hematoporphyrin derivative (HpD). Atherosclerotic rabbits were given 5mg/kg of HpD intravenously. Twenty-four hours after HpD administration, the aortae was exposed to 200mw output argon dye laser beam at 630nm for 10 minutes, or 400mw for 5 minutes. In these groups, most intimal cells and endothelial cells had become necrotic and disappeared, and a loss of intima was observed. And then, 5mg of HpD was applied to the atherosclerotic lesion on the aorta of each rabbit through a Dispatch catheter. The lesions were then exposed to 200mw output YAG-OPO laser beam at 630nm for 10minutes from the intimal side of the aorta. Results were almost same as given HpD intravenously. The above data suggest that PDT caused effective regression of the atherosclerotic lesions.
- Japan Society for Laser Surgery and Medicineの論文
Japan Society for Laser Surgery and Medicine | 論文
- Photodynamic Therapy (PDT) with Hematoporphyrin Derivative (HpD) for Atherosclerotic, Lesions in Rabbits:-Dosage, Administration route of HpD and Effectiveness of a New Fiber for PDT-
- Application of laser in restorative dentistory, endodontology and periodontology
- Photodynamic Therapy in Early Lung Cancer
- Effects of He-Ne Low-powered Laser on Red Cell Deformability
- Treatment of cutaneous vascular lesions with Diode-pumped, frequency double solid-state laser Dio ite®532 Laser System