Study of the characteristics of gastroesophageal reflux disease (NERD, in particular) as discovered in a mass survey.

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We studied the characteristics of gastroesophageal reflux disease (GERD) as discovered by a mass survey which lasted from November 2004 to September 2005. The subjects were 691 persons, each of whom underwent a medical examination by upper-gastrointestinal endoscopy at our medical examination center. There were 526 male and 165 female subjects, and their average age was 52.6 years. The incidence of reflux esophagitis and NERD was 12.2% and 10.4%, respectively.<BR>Using multivariable analysis, we investigated the factors which affect the onset of GERD. Young age (odds ratio: 0.40, 95% C. I.: 0.17-0.81, p<.05), female gender (odds ratio: 0.61, 95% C. I.: 0. 17-0.84, p<.05) and smoking (odds ratio: 1.95, 95% C. I.: 1.15-4.99, p<.05) were the risk factors of NERD. On the other hand, the risk factors of reflux esophagitis were esophageal hiatal hernia (odds ratio: 12.38, 95% C. I.: 6.41-21.0, p<.01), slight atrophy of the gastric mucosa (odds ratio: 0.14, 95% C. I.: 0.04-0.29, p<.01), male gender (odds ratio: 4.85, 95% C. I.: 1.17-7.97, p<.02) and obesity (odds ratio: 2.45, 95% C. I.: 1.01-3.44, p<.05). Because obesity and smoking were associated with the onset of reflux esophagitis and NERD, respectively, we concluded that GERD is one of the lifestyle-related diseases. It was suggested that the modification or eradication of certain habits might lead to the prevention of GERD.
一般社団法人日本消化器がん検診学会の論文