Effect of conjugated linoleic acid during pregnancy and lactation on growth and liver triacylglycerol content in offspring of mice

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Effects of dietary conjugated linoleic acid (CIA) during pregnancy and lactation on mater nal and offspring body weight, and liver condition of offspring were determined. Mice at 8weeks-of-age were divided into two groups. They were provided free access to one of two semi-purified diets containing 30 g CLA plus 70 g soybean oil/kg diet (CLA group) or 100 g soybean oil/kg diet (control group). At 9 weeks-of-age female mice were mated with male mice given the same diet. Female mice were fed the experimental diets until their offspring became 25 days old. The liver was removed from offspring and the triacylglycerol content was determined. Although body weight of dams was not significantly different between dietary groups, the body weight of offspring exposed to dams given CLA was lower compared with the controls. The relative liver weight and triacylglycerol content of offspring in the CLA group were significantly higher than those of control. These results suggest that CLA supplementation during pregnancy and lactation influences growth and liver lipid metabolism of offspring in mice.
日本ペット栄養学会の論文