薬剤による肝障害
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概要
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Fourteen suspected cases of drug-induced hepatitis were diagnostically confirmed by determinating serum enzyme activities following provocative readministration of causative agents.<BR>After recovery of their clinical course, the 14 cases were readministrated about half a daily dose of their respective causative agent. Then, the activities of several seru m enzymes were chronologically determined. In 24-48 hours, all cases showed a marked increase in glucose-6-phosphatase, isocitric dehydrogenase and aldolase.<BR>Rabbits with experimental liver injury induced by 2-hydroxy-methylene-17 α-methyldihy-drotestosterone showed almost identical results in serum enzyme activities as with those of human cases.<BR>Comments are made on the sorts of inducing drugs, incubation periods, symptoms and signs, clinical course, laboratory data, histological findings in liver biopsies, diagnosis, treatment and pathogenesis of drug-induced hepatitis.
- 関西医科大学医学会の論文
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