Changes in the Expression of Transforming Growth Factor-α and Lewis y Antigen with the Malignant Transformation of Oral Leukoplakia into Squamous Cell Carcinoma

概要

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The purpose of this study was to examine the differences in immunohistochemical staining for transforming growth factor-α (TGF-α) and Lewisy antigen (Le y) in pathologic specimens of squamous cell carcinoma (SCC), leukoplakia, and epithelial dysplasia. For this purpose, ten cases of SCC developing from oral leukoplakia and thirty-five cases of leukoplakia with epithelial dysplasia, yet to develop into SCC, were investigated immunohistochemically. Proliferating cell nuclear antigen (PCNA) staining was used as a marker of cell proliferating activity. The results showed that the expression of TGF-α and PCNA increased, whereas that of Le y decreased with the malignant transformation into SCC. In case of leukoplakia with epithelial dysplasia, the expression of PCNA, TGF-α and Ley did not show an obvious correlation with the grade of epithelial dysplasia. These results suggest that TGF-α and Le y may be concerned with tumor growth, but not with the progression of epithelial dysplasia.
昭和大学・昭和歯学会の論文