ＲＡ生物学的製剤使用例における周術期管理

概要

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Objective: We examined the safe perioperative management of orthopaedic surgery in the patients with rheumatoid arthritis who were being treated with biological agents.Materials and methods: Twenty-four patients were divided into an Infliximab group (n=17) and an Etanercept group (n=7), and we assessed the changes in disease activity in the perioperative period and the incidence of postoperative complications.Results: A flare-up in the postoperative period occured in 2 patients in the Infliximab group and in all patients in the Etanetcept group. A postoperative wound surface infection developed in one patient in the Infliximab group. Poor wound healing was observed in two patients in the Etanercept group, but both wounds healed promptly in response to appropriate treatment.Conclusion: There were no serious complications in any of the patients in this study. Safe perioperative management appered to be possible in patients being treated with biological agent, but attention should be paid to wound healing in such patients.
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