Neurochemical and behavioral effects of excessive glucose intake in thiamine-deficient mice

概要

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Thiamine (vitamin B1) plays some important roles in the central nervous system (CNS) control of animal behavior, but its detailed mechanism has not been clarified. Thiamine has a central role in glucose metabolism; therefore, it has been speculated that thiamine deficiency (TD) induces CNS dysfunction, for example, cognitive impairment is mainly due to the dysfunction of energy metabolism in the brain. In the present study, to confirm the mechanism by which TD induces dysfunctions in the CNS, we administered thiamine-deficient diets and diets with excessive glucose for 10 days and observed behavioral changes and neurochemical changes in the brain. TD inhibited habituation learning and excessive glucose impaired shortterm memory. TD influenced L-lysine levels in the hippocampus and excessive glucose affected dopamine and noradrenaline levels in the cerebral cortex. A significant interaction was observed between TD and excessive glucose levels in hippocampal serotonin metabolism, while the corresponding behavioral change was not observed in habituation learning. These results indicate that not only energy dysfunction but other mechanisms may be involved in TD-induced CNS dysfunction.
日本ペット栄養学会の論文