Controlled Calcification using Polyanionic Macromolecules with an Active Reaction Center Analogue of Carbonic Anhydrase
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概要
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Biomimetic macromolecules containing carboxyl and imidazole groups were synthesized. The complex of a zinc ion, a water molecule, and three imidazoles in a polymer is expected to act as an active center analogue of carbonic anhydrase, a hydration enzyme. The obtained polymer complex was applied to calcium carbonate formation. In this study, we investigated the role of both functional groups on the calcification reaction. The presence of a carboxyl group drastically enhanced the biomineralization, because it recognized and condensed the calcium ion at the first step of the calcification reaction. The obtained zinc-imidazole complex selectively induced the formation of vaterite, which is well-known to be a thermodynamically metastable polymorph of calcium carbonate. Interestingly, the results suggest that the active center analogue (zinc-imidazole complex) also stimulates introduction of the HCO3- ion to the calcium ion-recognition site.
- ナノ・バイオメディカル学会の論文
ナノ・バイオメディカル学会 | 論文
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