TO EXAMINE THE ADVERSE PHOTOTHERMAL EFFECTS OF EXTENDED DOSAGE LASER THERAPY IN VIVO ON THE SKIN AND SUBCUTANEOUS TISSUE IN THE RAT MODEL
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概要
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The incidence of the use of the laser in laser therapy, or LLLT, rather than laser surgery, has been reported as increasing in many areas, While the applications of LLLT increase, concern has been expressed in the literature regarding the possible damage to tissue following extended doses of laser radiation having low incident power densities, such as are used in laser therapy. The present study was designed to evaluate any such adverse effects of 830 nm infrared laser energy (60 mW, continuous wave, spot size 0.3 cm2, power density ≅ 0.2 W/cm2, irradiation times of 3 and 30 min, energy densities 36 J/cm2 and 360 J/cm2, respectively) in vivo on rat skin and subcutaneous tissue, with normal and extended dosage at a low incident power density. A third group of unirradiated but identically handled animals acted as the control. Evaluation was made both macroscopically, recorded photographically, and microscopically with haematoxylin-eosin (HE) staining of histological specimens. Additional evaluation of tissue temperature rise as a function of irradiation time was recorded using digitalized thermography. Histological samples were coded, randomized and evaluated by an independent histologist. Skin temperature at the irradiated area rose by 1.1 °C over the first 4 min of irradiation, and then remained constant at that level for the remainder of the 30-min irradiation period. Macroscopically, there were no visible signs of alteration of skin colour or texture. Histology revealed no difference in the epidermal, dermal and subdermal tissue architecture in control. 3-min and 30-min irradiated specimens. The authors conclude that, for the range of parameters quoted above, laser therapy is inherently photothermally safe for in vivo irradiated tissue, bringing about no macroscopic or microscopic change in tissue architecture which could be classed as 'damage '.
- 国際光治療学会の論文
国際光治療学会 | 論文
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