ポラプレジンク含嗽液の新たな基剤に関する検討
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概要
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Objective: In The Hospital of Hyogo College of Medicine, a oral rinse containing polaprezinc (PZ), a zinc-containing drug for gastric ulcers, was used as a hospital preparation to treat radiotherapy-related oral mucositis, and its efficacy was reported. However, the dispersibility of PZ for carboxymethylcellulose sodium (CMC), which was used as the base of the oral rinse, was unfavorable, raising an issue. In this study, we newly prepared a PZ oral rinse containing carboxyvinyl polymer (CP) as a base, and examined its usefulness.Methods: A questionnaire survey regarding the usefulness involving 10 healthy volunteers and a pharmaceutical test were conducted.Results: The results of the questionnaire survey showed that the optimal concentration of CP was 0.5%. There were no serial changes in the pH, adhesiveness, or PZ content for 7 days after preparation. Furthermore, there were no differences between CMC and CP. The dispersibility of PZ in the oral rinse containing CP as a base was more favorable than that in the oral rinse containing CMC.Conclusion: The results of this study suggest that the PZ oral rinse containing 0.5% CP as a base is useful, and that its stability is similar to that of the oral rinse containing CMC as a base.
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