The Effect of Suplatast Tosilate on Eosinophil Number and Serum Level of Chemokine in Adult Atopic Dermatitis

概要

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For adult atopic dermatitis patients, the effect of Suplatast Tosilate was examined by clinical observation, IgE level, LDH, eosinophil number, and serum concentrations of eotaxin2 and IP-10. We treated patients with either Suplatast Tosilate or other anti allergic agents (control group). The clinical observation was improved in both groups, but the decrease in serum IgE level could not be detected. By contrast, the significant decrease in LDH was observed only in the Suplatast Tosilate-administrated group. Furthermore, eosinophil number decreased. However, the decline of LDH and eosinophil number could not be found in the control group. In the Suplatast Tosilate-administrated group, eotaxin2 was decreased in 2 out of 4 serum samples, and it was unchangeable in the 1 serum sample. In the average, mean eotaxin2 level decreased from 212.6 pg/ml to 167.9pg/ml. These results suggest that Suplatast Tosilate exhibits inhibitory effect for Th2 chemokine in adult atopic dermatitis.
日本皮膚科学会大阪地方会・日本皮膚科学会京滋地方会の論文