Use of Hepatic CYP1A1 Activity in Japanese Flounder to Monitor oil Dispersed from the Nakhodka Spill
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概要
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Cytochrome P4501A activities (measured as ethoxyresorufin-O-deethylase (EROD)) in the liver of flounder, <I>Paralichthys olivaceus</I>, were measured as a biomarker of the response to dispersed oil exposure. EROD activities in flounder administered crude oil (0.1, 0.3 and 1 mg/kg body weight/day) in their diets increased to more than 20-fold of those in control fish. The increased activities persisted for 6 days after cessation of exposure to heavy oil. These results demonstrated that EROD in the liver of Japanese flounder is a good biomarker of oil pollution. However, no significant increase in EROD activity was observed in flounder collected from Nakhodka oil spill areas compared with those collected from control sites.
- 日本環境毒性学会の論文
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