冷媒として使用されているハイドロフルオロカーボンの毒性評価
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概要
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The present paper summarizes data on the toxicity of hydrofluorocarbons(HFCs),including 1,1,1,2,2-pentafluoroethane(HFC-125),1,1,1,2-tetrafluoroethane(HFC-134a),1,1,1-trifluoroethane(HFC-143a),1,1-difluoroethane(HFC-152a),difluoromethane(HFC-32),and 1,1,1,3,3-pentafluoropropane(HFC-245fa),used as refrigerants, publishedin openly available scientific literature. Acute exposure to HFC-152a, but not otherHFCs, caused deaths in rats at 383,000 ppm. These HFCs, except for HFC-32, caused acardiac sensitization in dogs at high concentrations. Although myocarditis was found afterrepeated exposure to HFC-245fa for 13 weeks at 10,000 ppm and above, no overt toxicitywas noted after repeated exposure to other HFCs. HFC-134a, HFC-32, and HFC-245facaused developmental toxicity at 50, 000 ppm, but these HFCs were not teratogenic. Toxiceffects of HFC-134a are relatively well reported, but limited information is available regardingthe toxicity of other HFCs. Animal studies are necessary for risk assessments of chemicalsbecause it is difficult to find alternative methods to determine the toxic effects ofchemicals. It is important to reduce emissions of organic vapors containing HFCs toreduce the risk of exposure and protect public health.
- 日本環境毒性学会の論文
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