The effects of enteral feeding with eicosapentaenoic acid, γ-linolenic acid and antioxidant vitamins on mechanically ventilated patients with severe sepsis and septic shock: a retrospective analysis of Japanese-descendant patients

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• <B>Objective:</B> Enteral diets enriched with eicosapentaenoic acid (EPA), γ-linolenic acid (GLA) and antioxidant vitamins have been demonstrated to improve outcomes in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). There is ethnic difference in the distribution of genetic polymorphisms, and therefore, the efficacy of nutritional treatment may differ among races. We evaluated the efficacy of the enteral diet enriched with EPA, GLA and antioxidants in a Japanese-descendant population with ARDS secondary to severe sepsis or septic shock through a retrospective assessment of the original database of our previous study. <B>Materials and methods:</B> 18 Japanese-descendant patients were identified from the original study based on the ethnic answer on their clinical research forms. All patients were randomly assigned to two groups either with a diet enriched with EPA, GLA and antioxidant vitamins or with an isonitrogenous and isocaloric control diet, delivered at a constant rate to achieve a minimum of 75% of basal energy expenditure x 1.3 during a minimum of 4 days and monitored for 28-days. <B>Results:</B> Those who received the study diet experienced significant improvements in oxygenation status, more ventilator-free days (12.0±2.6 vs. 4.2±1.7, <I>P</I> = 0.0362) and more ICU-free days (8.9±2.2 vs. 2.6±1.2, <I>P</I> = 0.0348). No significant changes were observed in terms of the development of new organ failures and mortality outcomes. <B>Conclusions:</B> In Japanese-descendant patients with severe sepsis or septic shock and requiring mechanical ventilation and tolerating enteral nutrition, a diet enriched with EPA, GLA and antioxidants contributed to better ICU outcomes.

• 一般社団法人 日本集中治療医学会の論文

一般社団法人 日本集中治療医学会 | 論文

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