Three Cases of Passively Acquired anti-GAD Antibody Following Administration of Intravenous Gamma Globulin
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Passively acquired anti-glutamic acid decarboxylase (anti-GAD) antibodies were detected in three patients after administration of intravenous gamma globulin (IVIg) . Case 1: A 53-year-old man was given IVIg for treatment of Guillain-Barré syndrome had an anti-GAD level of 2.4 U/ml 30 days later. Case 2: A 67-year-old woman was given IVIg for treatment of hypogammaglobulinemia and acute respiratory distress syndrome due to bacterial infection; her anti-GAD level was 2.9 U/ml 22 days later. Case 3: A 73-year-old man was given IVIg for treatment of immune thrombocytopenic purpura (ITP) ; his anti-GAD level was 2.1 U/ml 12 days later. In these three cases, anti-GAD levels before and after IVIg therapies were normal. The anti-GAD levels in all lots of IVIg administrated to these three patients were 2.1-4.9 U/ml. In contrast, anti-GAD levels in a 79-year-old woman who was given IVIg for treatment of ITP was normal (Case 4). The anti-GAD level in the lot of IVIg administrated to this patient was 1.6 U/ml. These results indicate that the transient appearance of anti-GAD in the previous three cases was associated with IVIg administration, and suggest that evaluation of beta cell damage by measuring anti-GAD levels immediately after IVIg administration is difficult.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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