What is the Critical Hyperthermia Target in Cancer Cells?
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概要
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Currently, the molecular mechanisms involved in heat-induced cell killing are not completely understood, although protein denaturation is known to be the major target for hyperthermia in cancer cells. A new hypothesis is described here which proposes that heat-induced cell killing is associated with cellular DNA double-strand break (DSB) formation. This review provides details of this model for hyperthermia cell killing, and a possible mechanism to explain heat-induced DSB formation.
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