Restraint Plus Water-immersion Stress (RWIS)-induced Stomach Ulcers in Mice are Depressed by a Conditioning Heat Treatment
スポンサーリンク
概要
- 論文の詳細を見る
A conditioning mild heat treatment can depress subsequent severe heat-induced biological damage by inducing thermal tolerance. In the work described here, the effect of a conditioning mild heat exposure at 37°C was examined on the formation of gastric mucosa damage induced by a restraint plus water-immersion stress (RWIS) treatment in mice. RWIS treatments induced stomach ulcers in about 42% of the control animals, but a mild conditioning heat treatment at 37°C was found to depress the appearance of ulcers, and only about 9% of the pre-exposed animals developed ulcers. In addition, RWIS treatment induced an apoptosis rate in the stomach of about 13%, but a conditioning mild heat treatment depressed the apoptotic rate to about 8%. Since the heat shock protein (HSP) inducer geranylgeranylacetone (GGA) also efficiently depressed stomach ulcer incidence rates, it is suggested that gastric mucosa damage may be depressed by HSPs induced by a mild conditioning heat treatment through the depression of apoptosis.
- 日本ハイパーサーミア学会の論文
日本ハイパーサーミア学会 | 論文
- わが国における温熱療法のあゆみと現状:2004年のアンケート調査
- 癌治療における併用療法としての低温度温熱処置の有用性について
- The Biology of Heat-induced DNA Double-Strand Breaks
- 良好な生存率を示した非小細胞肺癌の化学療法とハイパーサーミアの併用療法
- 温熱感受性ならびに温熱効果の修飾について