巨赤芽球性貧血におけるメチルマロン酸尿中排せつ量と臨床病態
スポンサーリンク
概要
- 論文の詳細を見る
Urinary methylmalonic acid (MMA) excretion in megaloblastic anemia due to vitamin B12 (B12) deficiency was studied using a colorimetric method. Average MMA excretion in 20 patients with untreated B12 deficiency was 164 mg/day, whereas it increased to 518 mg/day following oral adnimistration of 10 g L-valine. Urinary MMA correlated significantly with platelet number, erythroblast percentage and deoxyuridine suppression test, while no correlation was found with hemoglobin, leukocyte number, reticulocyte, serum LDH, serum B12 and folate concentration. Patients with neurological disturbances excreted significantly larger amounts of MMA than those without neurological disorders.The results also indicated that MMA could be a useful adjunct for differentiation of megaloblastic anemia from myelodysplastic syndromes showing marked megaloblastic changes.
- 一般社団法人 日本血液学会の論文
一般社団法人 日本血液学会 | 論文
- 健常者ならびに播種性血管内凝固(DIC)例における血漿アンチトロンビンIII (AT-III)の抗トロンビン活性と抗原性の比較
- 新生児の凝固・線溶阻止因子の動態
- Ａｌｌ－ｔｒａｎｓ ｒｅｔｉｎｏｉｃ ａｃｉｄ投与中に広範な脳梗塞を生じた急性前骨髄球性白血病
- C/EBPβのショートアイソフォームであるLIPはマウス移植モデルにおいてEvi1と協調作用して急性骨髄性白血病を誘発する
- 成人に発症したビタミンＫ依存性血液凝固因子欠乏に関する臨床的解析