急転時ｔｒｉｐｌｏｉｄ ｃｌｏｎｅの出現をみた複雑相互転座ｔ（９；２２；１２）慢性骨髄性白血病の１例
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概要
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A 56-year-old female, who was diagnosed as CML in 1983 and had been well controled with busulfan, was admitted to our hospital because of fever and iliac bone pain. Peripheral blood showed leukocytosis (WBC 70,000/μl and bone marrow was normocellular with 53% leukemic cells, suggesting that she was in the blastic crisis.Chromosomal analysis of bone marrow cells at that time revealed t(9;22;12) and some additional abnormalities. The number of chromosomes ranged from 44 to 131 and the mode of chromosome number was 65.She was treated with combination regimen consisting of vincristine, 6-mercaptopurine and prednisolone and right iliac tumor was irradiated. Three months after admission, she died of DIC and pulmonary insufficiency due to leukemic infiltration.
- 一般社団法人 日本血液学会の論文
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