Ｐｈ｀１´陽性急性リンパ性白血病の１例
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概要
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A case of Philadelphia chromosome (Ph1) positive acute lymphoblastic leukemia is reported. The patient was 11 year old boy, who was admitted on Decemper 18, 1980 to out hospital with the chief complaints of fever and nasal bleeding. Physical examination showed moderate hepatosplenomegaly and petechiae. Laboratory examinations on admission revealed remarkable leukocytosis (174,000/mm3) with 90% of lymphoblasts in peripheral blood in adittion to thrombocytopenia. Blastic cells were Peroxidase negative, PAS negative and morphologically seemed to belong to L2 type ALL. Chromosomal study on peripheral plood cells showed that lymphoblasts had an abnormal karyotype of 46, XY, 1p+q-, t(9;22) (q34;q11). The patient reached a complete remission by the induction therapy consisted of VCR (1×/W ×5), L-asparaginase (every other day ×8) and prednisolone. He was given intrathecal injection of methotrexate and cranial irradiations of 2,400 rads as the prophylaxis of meningeal leukemia. Philadelphia chromosome was lost during remission. A hematological relapse occured soon after the completion of cranial irradiation and Ph1 chromosome became to be detected again. He received the re-induction therapy, for example, COAP, Asp-VDP and AAAP therapy, but failed to reach a remission. He became febrile with septicemia and died on August 17, 1981. At autopsy, infiltration of leukemic cells was seen in the bone marrow, lymphnodes, testicles, kidney, liver and spleen.
- 一般社団法人 日本血液学会の論文
一般社団法人 日本血液学会 | 論文
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