１同胞間にみられた家族性白血病の１家系

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Acute leukemia ocurred in siblings are reported. Elder sister, 10-year-old, was admitted to Narita Red Cross Hospital on October 19, 1974 because of fatigability. A peripheral blood examination revealed that white blood cells count was 7600/μl involving 6% monoblasts. She was diagnosed as having monocytic leukemia by bone marrow fims, and treated with prednisolone, 6-mercaptopurine and cytosine arabinoside, but she died on Novermber 15 with meningeal involvement. Her brother, 16-year-old, was admitted to Kasumigaura Hospital, Tokyo Medical College because of fever on Feburary 13, 1981. A peripheral blood examination on the admission revealed that Hb was 8.5g/dl, white blood cells count was 17800/μl involving 81% myeloblasts, and he was diagnosed as having acute myelogenous leukemia (Ml in FAB classification). Antileukemic agents (VCcMP and COAP therapy) were administrated to the patient, and a complete remission was achieved on April 17. Hematological and cytogenetic studies of their parents showed no abnormalities, and immunological examination revealed that the serum IgM of the father was only 50mg/dl, which was lower than the normal range (65-160mg/dl).
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