ひと赤血球の破壊

概要

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The clinical and experimental studies of the role of the spleen for red cell destruction were performed in hereditary spherocytosis (HS) and autoimmune hemolytic anemia (AIHA). Splenomegaly was evident in patients with HS and AIHA. The spleen size was well correlated with effective red cell destruction evaluated from daily hemoglobin degradation rate. Splenic surface counting in 51Cr labeled red cell survival studies showed an immediate rapid destruction followed by a gradual destruction in HS. In AIHA, labeled red cells were destructed in constant rate.Splenectomy is often considered in HS with good results. In AIHA, however, number of cases with good results was 50%. These clinical results suggest the spleen has a different role in hemolysis of spherocytes and antibody coated cells.In C3H mice, the red cell destruction of spherocytes and antibody coated cells was examined by using 59Fe labeled heat damaged red cells and cells treated with anti-C3H-erythrocyte-sera. Heat damaged cell destruction was depressed in splenectomized mice, which were treated by the previous intra-venous injection of heat damaged, nonlabeled red cells as the blockade of RES, but the antibody coated red cells were not depressed. These experiments suggest spherocytes were predominantly destructed into the spleen and antibody coated cells were broken down in spleen, liver or other RES organs.
一般社団法人日本血液学会の論文