L-asparaginase治療時の血中抗体形成について

概要

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The most peculiar form of toxicity observed in patients on L-asparaginase therapy would be hypersensitivity reactions.A precipitating antibody could be demonstrated in two patients, who developed allergic reactions during treatment with this enzyme preparations.It has been shown that the antibody is directed against the enzyme specifically and not against any of the impurities by Kohn's method.Antibody was detected on 13th L-asparaginase therapeutic day in one patient, 22th in another patient and on the day 14 after the immunization in the rabbits, which developed allergic reactions by i.v. administration of L-asparaginase on the day 28.We could demonstrate reagins, i.e. IgE antibodies in one patient.The relationship between antibody formation and allergic manifestations, and the possible new method of using this enzyme were discussed.
一般社団法人日本血液学会の論文