SLEにおけるANF.: その病因的意義について
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概要
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The present report deals with anti-nuclear factor (ANF) in the patients with systemic lupus erythematosus (SLE) concerning possible role on pathogenesis of lupus nephritis.Results:1) Sera from the patients with active lupus nephritis demonstrated high value of DNA binding activity by tritiated ActinomycinD-DNA method and low complement level as well as DNA-like substance by precipitin test.2) Four distinct patterns of glomerular staining, linear, mesangial, granular and lumpy pattern were observed by fluorescent antibody technique.3) Linear and mesangial pattern were found in the patients with no renal damage. Granular and lumpy pattern, showing marked deposition of immunoglobulin and complement, were observed in the patients with active lupus nephritis.4) ANF was eluted from the glomeruli of active lupus nephritis showing lumpy pattern by acid buffer treatment.These data might show considerable evidence that antigen-antibody complexes composed nuclear antigens and ANF including anti DNA antibody may play the important role on pathogenesis of lupus nephritis.
- 一般社団法人 日本血液学会の論文
一般社団法人 日本血液学会 | 論文
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