Comparison of pharmacological effects of Yanbian Toki, Yamato Toki and Hokkai Toki (Angelicae Radix) on oketsu (blood stagnation) and hie-sho (chilliness) in animal models
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Previous reports suggest that Yanbian Toki (<I>Angelica</I> species of northeast China) may become an alternative resource of Angelicae Radix (Toki) when compared with the Japanese indigenous plants of <I>A. acutiloba</I> Kitagawa (Yamato Toki) and <I>A. acutiloba</I> var. <I>sugiyamae</I> Hikino (Hokkai Toki) in their similar chemical and genetic characteristics. In the present study, the pharmacological effects of Yanbian Toki on <I>oketsu</I> and <I>hie-sho</I> were assessed by using animal models in comparison with Yamato Toki and Hokkai Toki.<BR><I>Oketsu</I> state (stagnation of blood) was induced in mice by a consecutive injection of betamethasone (1.6 mg/kg/day, <I>i.m.</I>). Changes in peripheral blood flow of <I>oketsu</I> mice treated with each Toki extract at a dose of 200 mg/kg were examined both in single and repeated administrations. Yanbian Toki improved the peripheral blood flows of <I>oketsu</I> mice as well as Yamato Toki and Hokkai Toki, and showed no significant statistically differences.<BR>In <I>hie-sho</I> (chilliness) model, accomplished by submerging the rats in cold water, the restoration of body surface temperature was accelerated by a single administration of each Toki extract (200 mg/kg). Especially at the initial 5 min, it was significant. Furthermore, the time versus recovery effect was statistically significant in the treatment of Yamato Toki. However, there were no significant differences among them in their recovery effects. <BR>In both experiments, among Yanbian Toki, Yamato Toki and Hokkai Toki, there were no significant differences in their effects on <I>oketsu</I> and <I>hie-sho</I>. These results suggested that Yanbian Toki is pharmacologically comparable to Yamato Toki and Hokkai Toki.
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