Pharmacological properties of traditional medicine (XXXI)1): Anxiolytic effect of Hangeshashinto and the combinations of its major constituents on rat experimental colitis
スポンサーリンク
概要
- 論文の詳細を見る
Hangeshashinto (HST) has been used as an herbal formula to treat inflammatory ulcerative gut diseases complicated with psychoneurosis in Japanese traditional Kampo medicine. In our previous study, we revealed that HST improved rat inflammatory colitic symptoms induced by the intracolonic instillation of 2,4,6-trinitrobenzene sulfonic acid (TNBS). The aim of the present study is to clarify the anxiolytic effect of HST in the same model. The anxiety-like behavior was measured using an elevated plus maze (EPM). TNBS-treatment reduced the exploring time spent on the open arms of EPM, suggesting that as anxiety-like behavior was observed. This behavior was significantly improved by daily oral administration of HST. To identify the active constituents for this anxiolytic effect, berberine (BE), baicalin (BA), glycyrrhizin (GL) or saponin fraction of ginsenosides (GS), or their combinations were tested. Oral treatment with these four constituents significantly ameliorated the exploration time spent on open arms, although no effects were found in the treatment with each of BA, BE, GL or GS. Among the combinations in these 4 constituents, the combination of BA and BE exerted the anxiolytic effect, however, the combination of GL and GS, which is the active combination to improve colitic symptoms (damage score, colonic wet weight and ulcerative area) in our previous study (Kawashima et al. Biol. Pharm. Bull. 27, 1599, 2004), did not show any improvement. These results suggest that HST would have anxiolytic effect, which would be partially derived from the combination of BA and BE, and HST ameliorated the colitis, which would be partially derived from the combination of GL and GS, in TNBS-colitis model.
- 和漢医薬学会の論文
和漢医薬学会 | 論文
- S3-04 潰瘍性大腸炎に対する柴苓湯の効果(シンポジウム3 新しい消化管治療学-西洋医学の欠点を補う和漢薬の実力-,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
- C-14 マウス摘出下部消化管標本におけるワサビ成分アリルイソチオシアネートの平滑筋収縮作用 : 低温感受性チャネルTRPA1の関与(消化器・チャンネル,一般演題口演,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
- P-42 生姜成分ジンゲロールのバニロイド受容体を介する胃損傷抑制作用
- 附子アルカロイドメサコニチンの血管内皮 NO 遊離作用に関与する細胞内 Ca^ 上昇の機序 : 循環器
- P-37 釣藤鈎アルカロイド Hirsutine および Dihydrocorinantheine の心筋活動電位に対する作用