Effect of Sairei-to on signal transduction of the vasopressin V2 receptor in rat renal cortex
スポンサーリンク
概要
- 論文の詳細を見る
Sairei-to (TJ-114), a traditional Japanese medicine, has been used clinically for the treatment of various edematous disorders. The inhibitory effect of TJ-114 on edema may be dependent on the diuretic response it invokes. The present study was performed to determine the effect of TJ-114 on the anti-diuretic hormone vasopressin, which is implicated in the retention of water in various edematous disorders. TJ-114 (0.5-1.5 g/kg) was administered intra-duodenally to pentobarbital-anesthetized rats. Specimens of the renal cortex were isolated 30min after the administration and incubated in buffered Hank's balanced salt solution with vasopressin. The vasopressin-stimulated cAMP production was dose-dependently attenuated in renal tissues in rats treated with TJ-114. The inhibitory effect of TJ-114 was diminished by pre-treatment with N<SUP>G</SUP>-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor. Therefore, TJ-114 may inhibit stimulation of the vasopressin V2 receptor which is closely related to nitric oxide production.
- 和漢医薬学会の論文
和漢医薬学会 | 論文
- S3-04 潰瘍性大腸炎に対する柴苓湯の効果(シンポジウム3 新しい消化管治療学-西洋医学の欠点を補う和漢薬の実力-,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
- C-14 マウス摘出下部消化管標本におけるワサビ成分アリルイソチオシアネートの平滑筋収縮作用 : 低温感受性チャネルTRPA1の関与(消化器・チャンネル,一般演題口演,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
- P-42 生姜成分ジンゲロールのバニロイド受容体を介する胃損傷抑制作用
- 附子アルカロイドメサコニチンの血管内皮 NO 遊離作用に関与する細胞内 Ca^ 上昇の機序 : 循環器
- P-37 釣藤鈎アルカロイド Hirsutine および Dihydrocorinantheine の心筋活動電位に対する作用