New Types of Liposidomycins Which Inhibit Bacterial Peptidoglycan Synthesis Produced by Streptomyces.

概要

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Liposidomycins are atypical lipid-bearing nucleoside antibiotics that inhibit bacterial peptidoglycan synthesis. A producing strain was identified as a <I>Streptomyces</I> sp. from its cultural characteristics and physiological properties. It produced new types of liposidomycins that lacked sulfate and/or 3-methylglutaric acid moieties present in known liposidomycins by changing medium components. Liposidomycins which have no sulfate moiety, exhibited more potent antimicrobial activity. Thus liposidomycins are the unique antibiotics showing highly specific inhibition toward bacterial peptidoglycan synthesis and could be a useful clinical antibiotic agent.
日本放線菌学会の論文