Brasilicardin A; a New Terpenoid Antibiotic Produced by Nocardia brasiliensis.
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概要
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Our recent search for bioactive compounds from pathogenic <I>Nocardia</I> resulted in the isolation of a new antibiotic, brasilicardin A, from <I>Nocardia brasiliensis</I> IFM 0406, a clinical isolate from a lung nocardiosis patient. Brasilicardin A is a novel tricyclic diterpenoid containing an amino acid moiety, 3-hydroxybenzoate, a rhamnose and an <I>N</I>-acetylglucosamine unit. The antibiotic exhibited immunosuppressive activity in a mouse mixed lymphocyte reaction (MLR) assay system and its IC<SUB>50</SUB> value was 0.057 μg/ml. Its immunosuppressive mechanism was considered to be different from that of the reference drug, cyclosporin A (CyA), because brasilicardin A has no inhibitory activity against IL-2 production in mouse MLR assay. Also new bioactive substances which were recently isolated by our research groups from pathogenic <I>Nocardia</I> are reviewed.
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