キャピラリー電気泳動を用いたびらん剤分解物分析法

概要

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Screening methods for blister agent hydrolysis products in an aqueous sample using capillary electrophoresis (CE) have been developed. Thiodiglycol, the hydrolysis product of mustard gas (HD) was analyzed by micellar electrokinetic chromatographic (MEKC) mode with direct ultraviolet detection at 200 nm, and the limit of detection (LOD) and within-day repeatability were 1.2 μg/ml and ≤2.8%, respectively. N-Ethyldiethanolamine, N-methyldiethanolamine and triethanolamine, which are the hydrolysis products of nitrogen mustard 1, 2 and 3 (HN-1, 2, 3) were analyzed by capillary zone electrophoretic mode using cation complexing reagent with indirect ultraviolet detection at 214 nm, and LOD and within-day repeatability were 150 ng/ml, ≤9.7%, 135 ng/ml, ≤8.2%, 90 ng/ml, ≤14.2%, respectively. It was concluded that hydrolysis products of HD and HN-1, 2, 3 in aqueous solution can be determined by the above-mentioned two kinds of CE methods, respectively.
日本法科学技術学会の論文