Simultaneous Determination of 8-hydroxydeoxyguanosine, a Marker of Oxidative Stress, and Creatinine, a Standardization Compound, in Urine
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Recently, H. Kasai reported an automatic, precise method of 8-hydroxydeoxyguanosine (8-OH-dG) analysis in urine by high performance liquid chromatography coupled to an electrochemical detector (HPLC-ECD). It is based on a cleaning-up step by anion-exchange chromatography and a further purification step using reverse phase chromatography before detection by the ECD. In this communication, we report a method for the simultaneous determination of 8-OH-dG and creatinine, an internal standard for normalizing the excretion of 8-OH-dG in urine.
- 独立行政法人 労働安全衛生総合研究所の論文
独立行政法人 労働安全衛生総合研究所 | 論文
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