Ｐｈｏｔｏａｇｉｎｇと弾性線維

概要

論文の詳細を見る
Long-standing UV exposure causes accumulation of degenerated elastic fibers in the dermis. This phenomenon is termed as solar elastosis and considered to be a histological marker of photoaging. The molecular mechanism by which the degenerated elastic fibers accumulate in the dermis by long-standing UV irradiation remains unknown, but three possible theories have been proposed; suppression of elastic fiber degradation (1)by leukocyte elastase inhibitor (elafin), (2)by advanced glycation end product (AGE) modification of elastin molecule, (3)by racemization of aspartic acid residue of elastin molecule. Leukocyte-derived elastase inhibitor (elafin) was found to (1)colocalize with elastic fiber accumulations in the dermis, (2)bind to elastin molecule via transglutaminase <I>in vitro</I>, (3)be induced by UVA irradiation, and (4)protect elastin molecule from elastolytic degradation. Abnormal accumulation of elastic fibers in solar elastosis therefore may be a secondary response preventing the elastic fibers from leukocyte elastase attack.
日本炎症・再生医学会の論文