NF-.KAPPA.B activation pathway in thymic epithelial cells controls establishment of self-tolerance
スポンサーリンク
概要
- 論文の詳細を見る
Thymic epithelial cells (TEC) play pivotal roles in the establishment of self-tolerance through critical dialogue with developing thymocytes. Unique actions of NF-κB activation pathway within TECs for the establishment of self-tolerance have recently been highlighted by studies using a strain of mouse bearing a natural mutation of the NF-κB-inducing kinase (NIK) gene (<I>aly</I> mice) and gene-targeted mice of IκB kinase α (IKKα). <I>NIK</I>-mutant strain manifests autoimmunity and disorganized thymic structure with abnormal expression of Rel proteins in the stroma. The autoimmune disease seen in <I>NIK</I>-mutant mice was reproduced in athymic nude mice by grafting embryonic thymus from <I>NIK</I>-mutant mice. Similarly, an autoimmune-disease phenotype was induced in nude mice by grafting embryonic thymus from IKKα-deficient mice. The thymic microenvironment that caused autoimmunity in NIK- and IKKα-dependent manner was associated with defective processing of NF-κB2, resulting in the impaired development of thymic epithelial cells. Thus, a novel function for NIK-IKKα pathway in thymic organogenesis for the establishment of central tolerance has emerged.
- 日本炎症・再生医学会の論文
日本炎症・再生医学会 | 論文
- 新規キノリノン誘導体TA-270の炎症性気道疾患に対する効果
- Salazosulphapyridine, Predonizolone の好中球機能に及ぼす影響と Sodium ferrous citrate との併用効果についての検討
- Sodium ferrous citrate の好中球機能に及ぼす影響
- Mesalazine(Pentasa) の好中球機能に及ぼす影響と Sodium ferrous citrate(SFC) との併用効果についての検討
- 非ウイルスベクターによる細胞標的法の開発