血小板粘着，細胞接着性を制御したコラーゲンの血管修復材への応用

概要

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Our previous study indicated that He+-irradiated collagen grafts with a fluence of 1×1014 ions/cm2 have excellent blood compatible properties. Also, the collagen grafts demonstrated a high antithrombogenicity and graft patency. 150 keV-He+ irradiated collagen with a fluence of 1×1014 ions/cm2 simultaneously has the 2 properties of antithrombogenicity and cell attachment. In vitro platelet adhesion and plasma protein adsorption were evaluated to investigate the mechanisms of antithrombogenicity of these surfaces. Antithrombogenicity of the He+-irradiated collagen was caused by the reduction of the plasma protein adsorption such as the von Willebrand factor by ion beam irradiation. He+-irradiated collagen surfaces will be useful for the substrates of small-diameter vascular grafts.
一般社団法人日本脳卒中の外科学会の論文