Evaluation of Fc.EPSILON.RI-binding serum IgE in patients with ocular allergic diseases.
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概要
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We evaluated high-affinity receptor for IgE (FcεRI)-binding serum IgE in patients with atopic kerato- conjunctivitis (AKC; n = 31) and with seasonal allergic conjunctivitis (SAC; n = 13) by enzyme-linked immunosorbent assay (ELISA) using a recombinant soluble form of the human FcεRIα ectodomain (soluble α). The quantities of FcεRI-binding IgE are compared with those of total IgE measured by a conventional sandwich ELISA. Both of the quantities of FcεRI-binding and total IgE in AKC were significantly larger than those in SAC (P < 0.001). In contrast, the proportion of FcεRI-binding IgE (FcεRI-binding IgE/total IgE; %) in SAC was significantly larger than that in AKC (P < 0.001), although significant reverse correlation was observed between the proportion of FcεRI-binding IgE and total IgE in both AKC and SAC. Significantly, a higher proportion of FcRI-binding IgE in SAC than that in AKC may reflect the differences in pathologic states of AKC and SAC that are caused by a disparity in immune responses in these diseases.
- Japanese Society of Allergologyの論文
Japanese Society of Allergology | 論文
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